Abstract: In this paper, the effects of four cationic collectors (Dodecyl amine, Dodecyl trimethyl ammonium chloride, GE-609, N-Laurel ethanediamine) on the flotation behaviors of hematite and quartz were investigated. The results showed that the four cationic collectors all have a certain collection effect on quartz and hematite, while their abilities to capture quartz were stronger than hematite. In the four collector systems, starch had an obvious inhibitory effect on hematite. For quartz, in addition to the inhibitory effect of starch on the quartz in the N-dodecylethylenediamine system, the starch has less effect on quartz flotation in the other three collector systems. The mixed minerals flotation test results showed that compared with dodecyl amine and N-Laurel ethanediamine, the concentrate Fe grade and Fe recovery indexes were relatively better with the collectors of dodecyl trimethyl ammonium chloride and GE-609. The results of the mixed minerals flotation test and the single mineral flotation was consistent.